In patients with EE, NEXIUM provided day and night symptom relief over 24 hours1-3
The percent of heartburn-free* nights with NEXIUM 40 mg at week 4 ranged from 85%–91%, based on patient diaries from 3 studies.†1-3
With NEXIUM 20 mg, the percent of heartburn-free† nights at week 4 ranged from 84%–86%, based on patient diaries from 2 studies.†2,4
The percent of heartburn-free* days with NEXIUM 40 mg at week 4 ranged from 73%–75%, based on patient diaries from 3 studies.†1-3
With NEXIUM 20 mg, the percent of heartburn-free† days at week 4 ranged from 69%–73%, based on patient diaries from 2 studies.†2,4
*Heartburn-free defined as patient-recorded symptom of “none.”
†Secondary end points from 4 multicenter, randomized, double-blind trials comparing oral doses of NEXIUM vs omeprazole, administered once daily to patients with endoscopically diagnosed EE. Primary end point was healing of EE at week 8 (N=2425),1 (N=1960),2 (N=1148),3 (N=1175).4
NEXIUM 20 mg is the FDA-approved dose for the symptom relief of GERD.
NEXIUM 40 mg and NEXIUM 20 mg are the FDA-approved doses for the healing of EE. There is no correlation between symptom relief and the healing of EE with NEXIUM.
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1. Richter JE, Kahrilas PJ, Johanson J, et al. Am J Gastroenterol. 2001;96:656–665.
2. Kahrilas PJ, Falk GW, Johnson DA, et al. Aliment Pharmacol Ther. 2000;14:1249–1258.
3. Schmitt C, Lightdale CJ, Hwang C, et al. Dig Dis Sci. 2006;51:844–850.
4. Lightdale CJ, Schmitt C, Hwang C, et al. Dig Dis Sci. 2006;51:852–857.
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