NEXIUM® has a demonstrated safety and tolerability profile.
NEXIUM should be used only for the conditions, dosages, and durations specified in the Prescribing Information. Before prescribing NEXIUM, please see the full Prescribing Information (PDF – 303 KB).
Drug interaction studies have shown that NEXIUM does not have any clinically significant interactions with1:
Postmarketing reports of changes in prothrombin measures have been received among patients on concomitant warfarin and esomeprazole therapy. Patients treated with proton pump inhibitors and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time.
Avoid concomitant use of NEXIUM with clopidogrel, due to a reduction in plasma concentrations of the active metabolite of clopidogrel. When using NEXIUM consider alternative anti-platelet therapy.
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts, erlotinib, and digoxin).
Combined inhibitor of CYP 2C19 and 3A4 may raise esomeprazole levels.
Concomitant use of NEXIUM and St. John’s wort or rifampin can substantially decrease NEXIUM concentrations. Avoid concomitant use.
Concomitant use of NEXIUM and atazanavir or nelfinavir is not recommended because the plasma concentrations and therapeutic effects of those antiretroviral drugs may be reduced.
NEXIUM may increase the plasma levels of saquinavir. Dose reduction of saquinavir should be considered.
Concomitant use of NEXIUM and methotrexate may increase and prolong the serum levels of methotrexate and/or its metabolite. In high-dose methotrexate administration, a temporary withdrawal of NEXIUM may be considered in some patients.
For more information, click here to see the full Prescribing Information (PDF – 303 KB).
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1. Prescribing Information for NEXIUM, AstraZeneca Pharmaceuticals LP, Wilmington, DE.
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