Mean plasma concentration over time in patients with GERD after 5 days’ dosing*1
No cause-and-effect relationship has been established between pharmacokinetic data and clinical effectiveness.
No significant difference in clinical effectiveness has been shown between equal doses of NEXIUM and omeprazole.
Geometric mean AUC†1
NEXIUM 40 mg: 12.64 µmol/h/L‡
NEXIUM 20 mg: 4.18 µmol/h/L‡
omeprazole 20 mg: 2.34 µmol/h/L
†Area under plasma concentration–time curve.
*Data from a randomized, double-blind, crossover study comparing NEXIUM 40 mg, NEXIUM 20 mg, and omeprazole 20 mg, administered orally, once daily for 5 days to patients with GERD symptoms.1
1. Prescribing Information for NEXIUM, AstraZeneca Pharmaceuticals LP, Wilmington, DE.
2. Lind T, Rydberg L, Kylebäck A, et al. Aliment Pharmacol Ther. 2000;14:861-867.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.