Pharmacokinetics
NEXIUM is metabolized differently
NEXIUM demonstrated excellent bioavailability
Mean plasma concentration over time in patients with GERD after 5 days’ dosing*1
- NEXIUM is the S-isomer of omeprazole, which consists of both S- and R-isomers2
- The S- and R-isomers are metabolized differently by the liver, resulting in higher plasma levels of the S-isomer than the R-isomer, following administration of equal doses2
No cause-and-effect relationship has been established between pharmacokinetic data and clinical effectiveness.
No significant difference in clinical effectiveness has been shown between equal doses of NEXIUM and omeprazole.
Geometric mean AUC†1
NEXIUM 40 mg: 12.64 µmol/h/L‡
NEXIUM 20 mg: 4.18 µmol/h/L‡
omeprazole 20 mg: 2.34 µmol/h/L
†Area under plasma concentration–time curve.
‡P<.0001.
*Data from a randomized, double-blind, crossover study comparing NEXIUM 40 mg, NEXIUM 20 mg, and omeprazole 20 mg, administered orally, once daily for 5 days to patients with GERD symptoms.1
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