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Dosage & Administration

NEXIUM® (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM for Delayed-Release Oral Suspension

NEXIUM for Pediatric Patients

NEXIUM® I.V. (esomeprazole sodium) for Injection

NEXIUM Delayed-Release Capsules and NEXIUM for Delayed-Release Oral Suspension1

NEXIUM Dosage Administration
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NEXIUM for Pediatric Patients

Dosage and administration of NEXIUM in pediatric patients 1 to 17 years old1

NEXIUM Dosage schedule for pediatric patients

NEXIUM Dosage Schedule
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NEXIUM I.V. for Injection for Adult Patients

Prepare and administer in 2 steps—no filter needed.3

3-minute intravenous injection (20 mg or 40 mg) following reconstitution3

To reconstitute: Draw up 5 mL of 0.9% Sodium Chloride Injection, USP, into a syringe and inject solution into a 20-mg or 40-mg vial of NEXIUM I.V. Mix thoroughly. Use within 12 hours of reconstitution.

To administer: Withdraw the reconstituted solution (5 mL) into a syringe and inject through an I.V. port over no less than 3 minutes.

10- to 30-minute intravenous infusion (20 mg or 40 mg) following reconstitution3

To reconstitute: Draw up 5 mL of 0.9% Sodium Chloride Injection, USP, Lactated Ringer Injection, USP, or 5% Dextrose Injection, USP, from a 50-mL bag into a syringe and inject into the vial of NEXIUM I.V. Mix thoroughly.

To administer: Withdraw the reconstituted solution (5 mL) into a syringe and inject back into the 50-mL bag. Administer as an I.V. infusion over 10 to 30 minutes. Stability times: NSS/12 hours, LR/12 hours, and D5W/6 hours.

 

NEXIUM I.V. for Injection should not be administered concomitantly with any other medications through the same intravenous site and/or tubing. The intravenous line should always be flushed with either 0.9% Sodium Chloride Injection, USP, Lactated Ringer’s Injection, USP, or 5% Dextrose Injection, USP, both prior to and after administration.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Store unopened vials away from light. Unopened vials may be stored at 77°F with excursions permitted from 59°F to 86°F.

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NEXIUM Data

Learn more about NEXIUM healing rates versus omeprazole and lansoprazole.

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Accessibility of NEXIUM

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Approved Uses

Healing of Erosive Esophagitis (EE)

NEXIUM 40 mg and NEXIUM 20 mg are indicated for short-term treatment (4 to 8 weeks) in healing and symptomatic resolution of diagnostically confirmed EE.

Maintenance of Healing of EE

NEXIUM 20 mg is indicated to maintain symptom resolution and healing of EE. Controlled studies did not extend beyond 6 months.

Symptomatic GERD

NEXIUM 20 mg is indicated for the short-term treatment (4 to 8 weeks) of heartburn and other symptoms associated with GERD.

Pediatric Use

NEXIUM is indicated for the short-term treatment (up to 8 weeks) of GERD (symptomatic GERD and healing of EE) in patients 1 to 17 years of age. Pediatric use is supported by extrapolation of results from studies that supported the approval for NEXIUM for adults and safety and pharmacokinetic studies performed in pediatric and adolescent patients.

Effectiveness has not been demonstrated in patients less than 1 year of age. Safety and effectiveness for other pediatric uses have not been established.

Important Safety Information

References
  1. Prescribing Information for NEXIUM.
  2. Zhao J, Li J, Hamer-Maansson J, et al. Clin Ther. 2006;28:1868-1876.
  3. Prescribing Information for NEXIUM I.V.